PROGNOSIS dan PREDIKTIF pada KANKER

Presentasi berjudul: "PROGNOSIS dan PREDIKTIF pada KANKER"— Transcript presentasi:

1 PROGNOSIS dan PREDIKTIF pada KANKER
April 15, 2018 PROGNOSIS dan PREDIKTIF pada KANKER dr. Daan Khambri, SpB(K)Onk, M.Kes Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RSUP Dr.M.Djamil Daan Khambri, Stase Nuclear Medicine

2 Curiculum Vitae Lahir di DUMAI, tanggal 6 Mei 1967
Dr. H. Daan Khambri, SpB (K) Onk, M.Kes Dokter Spesialis Bedah Konsultan Bedah Onkologi / HNB (Bedah Tumor) Lahir di DUMAI, tanggal 6 Mei 1967 Pendidikan : SD, SMP, SMA di DUMAI s/d Th 1985. S1 – Dokter Umum (FK-UNAND Padang, 1991). Sp1 – Spesialis Bedah (FK-UNAND Padang, 2003). S2 – Magister Kesehatan (FK-UNPAD Bandung, 2007). Sp2 – Konsultan Bedah Onkologi (FK-UNPAD Bandung, 2007). Pekerjaan :- Staf Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RSUP Dr.M.Djamil Organisasi Profesi : IDI, IKABI, PABI, PERABOI, POI Riwayat Pekerjaan : PUSKESMAS Rantau Pandan Bungo Tebo JAMBI. PUSKESMAS SALIMPAUNG Tanah Datar SUMBAR. RSUD SUNGAI DAREH Kab. DHARMASRAYA. RSUP Dr.M.Djamil / FK-UNAND Padang. Padang, 2012 Curiculum Vitae 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

3 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
BUKU RUJUKAN UICC, International Union Against Cancer. Prognostic Factors in Cancer. 3rd Ed Bradley KT. CAP Cancer Committee. Prognostic and Predictive Factors in Breast Cancer. Newspath. Sept Gede Sukardja. Onkologi Klinik. Edisi 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

4 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
CARA TERAPI KANKER SURGERY RADIATION THERAPY CHEMOTHERAPY HORMONAL THERAPY MOLECULAR-TARGET THERAPY 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

5 Combination Therapy : MULTIMODALITAS
15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

6 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

7 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
prognostic factor Definisi : a measurable variable that correlates with the natural history of the disease 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

8 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
prognostic factor Faktor yang dapat dipakai untuk meramalkan perjalanan penyakit kanker 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

9 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
PROGNOSTIC FACTOR PENDERITA TUMOR TERAPI 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

10 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
PENDERITA Umur Kelamin Suku Bangsa Genetik Status Umum Status Penampilan Imunitas Co-Morbiditas Gizi Sosial Ekonomi 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

11 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
TUMOR Topografi/Jenis Kanker Morfologi/Patologi Derajat Keganasan Stadium Luas Ekstensi Tumor Lokasi dan luas meta Reseptor Hormon Petanda Tumor Multisentris Radio/Khemo sensitivitas 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

12 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
TERAPI Jenis terapi Lengkap / tidak Radikalitas operasi Respon terhadap terapi Fasilitas Keahlian Dokter Kerjasama tim multidisiplin 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

13 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
Predictive Factor Definisi : is associated with response to a given therapy. 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

14 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
Predictive Factor Faktor prediksi adalah sesuatu yang berpengaruh secara spesifik terhadap jenis pengobatan tertentu 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

15 Prognostic Factors in Breast Cancer
Age Tumor size Axillary node status Histological tumor type Pathologic grade Hormonal receptor HER-2/neu 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

16 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
April 15, 2018 BREAST CANCER Stage I T1 N0 M0 T1a: T  0.5 cm T1b: 0.5 cm < T  1 cm T1c: 1 cm < T  2 cm T1 T  2 cm 35. Breast Cancer: Stage I Stage I disease T1 N0 M0 is common. T1 tumors are 2 cm in dimension. T1a tumors are 0.5 cm. T1b tumors are >0.5 cm, but 1 cm in greatest dimension. T1c tumors are 1 cm, but no more than 2 cm in greatest dimension. This early breast cancer is often diagnosed on screening mammograms. N0 = no regional lymph node metastasis M0 = no distant metastasis 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker Daan Khambri, Stase Nuclear Medicine

17 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
April 15, 2018 BREAST CANCER Stage IV Any T any N M1 40. Breast Cancer: Stage IV Stage IV, or metastatic, breast cancer is a lethal disease. The most common sites of metastases are soft tissue (skin or draining lymph nodes), bone, and viscera (eg, liver, lung). M1 = distant metastasis (including metastases to ipsilateral supraclavicular, cervical, or contralateral internal mammary lymph nodes) 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker Daan Khambri, Stase Nuclear Medicine

18 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
RESEPTOR HORMON Estrogen reseptor (ER) Progesteron Reseptor (PR) Epidermoid growth factor reseptor (EGFR) / Her2 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

19 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
JENIS RESEPTOR Reseptor hormon positif Reseptor hormon negatif Reseptor hormon menentukan sensitivitas kanker terhadap hormon 15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

20 Daan K, Blok 2.1 Prognosis & Prediktif Kanker
15/04/2018 Daan K, Blok 2.1 Prognosis & Prediktif Kanker