Metabolisme Susila Sastri.

Presentasi berjudul: "Metabolisme Susila Sastri."— Transcript presentasi:

1 Metabolisme Susila Sastri

2 Metabolisme Definisi: rangkaian reaksi-reaksi kimia dalam sel yang terjadi secara continue dan saling berhubungan satu dengan yang lain Anabolisme Katabolisme Ampibolic

3 Overview Metabolisme

4 Metabolisme Bahan bakar tubuh : carbohydrates, fats, dan proteins
( makromolekul) Energi : oxidasi :CO2 and H2O. Cadangan dalam tubuh : triacylglycerol (fat), glycogen (carbohydrate) Penurunan atau penambahan BB normal: Energi dipakai – Energi tersedia insulin dan glucagon; regulator pemakaian dan penyimpanan bahan cadangan Karbohidrat utama dalam darah : glukosa : regulator insulin dan glukagon dalam darah

5 Puasa Puasa : hypoglisemia , memicu pamkreas agar glukagon disekresi
Glucagon: cadangan carbohydrat membebaskan glucose ke sirkulasi ( brain) Puasa lebih 3 : ketone bodies (derived from fat) as an alternative fuel supply for the brain.

6 Anabolisme Biosintesis senyawa biomolekul (glikogen, protein, trigliserida) Butuh Energi (endergonic). ATP: ADP + Pi (ATP-ADP cycle) Misal Glikogenesis Glukoneogenesis Biosintesa asam lemak Biosintesa protein

7 Katabolisme Pemecahan molekul besar : molekul kecil (glukosa, asetil KoA, Asam amino) CO2 dan Energi (ATP) CO2 : sirkulasi ATP : dibebaskan setelah elektron ditransfer ke O2 Mis: Glikolisis Glikogenolisis Oksidasi asam lemak

8 Amphibolic Anabolisme dan Katabolisme: terjadi dalam satu proses metabolism Siklus Kreb Biosintesis heme, glukosa, asam lemak Katabolisme: sitrat, ketoglutarat

9 Energi Oxidation of fuels to generate ATP is called respiration
Electrons lost from the fuels during oxidative reactions : transferred to O2 by a series of proteins in the electron transport chain Energy of electron transfer : used to convert ADP and Pi to ATP by a process known as oxidative phosphorylation Satuan Energi : Calori kilocalorie kilojoules (kJ)

10 The ATP-ADP cycle

11 Generation of ATP

12 approximate order in which the processes occur
approximate order in which the processes occur. TG = triacylglycerols; FA = fatty acid; AA = amino acid; RBC = red blood cell; VLDL = very low density lipoprotein; I= insulin; % = stimulated by.

13 Metabolisme KH, Fat AA TAG = triacylglycerol

14 Overview Metabolisme KH

15 Overview of fatty acid metabolism

16 Overview of amino acid metabolism

17 Transport and fate of major carbohydrate and amino acid substrates and metabolites

18 Transport and fate of major lipid substrates and metabolites
FFA, free fatty acids; LPL, lipoprotein lipase; MG, monoacylglycerol; TG, triacylglycerol; VLDL, very low density lipoprotein.

19 Intracellular location and overview of major metabolic pathways