Neglected Disease Tutor 3 / A3

A3 Athari Nur Nathania Atika Primandina Nuri Aghnia Begin Koresi Rabiatul Adawiyah Fajar Faisal Sheila Aziza Fariz Dwiky Inez Aulia Syaiful Anwar Nurani Nasuha A3

An Overview of Neglected Disease Penyakit Infeksius yang terkesampingkan Penderitaan besar bagi kalangan ekonomi rendah di seluruh dunia endemik pada negara low- & middle-income namun negara tersebut kekurangan peralatan serta sumber untuk mengontrol penyakit tersebut secara penuh. Manfaat memahami neglected tropical diseases : menstimulasi perubahan pada rencana public health untuk melakukan pendekatan dan mencapai pengontrolan yang baik terhadap penyakit tersebut.

Why The Diseases Termed as ‘Neglected’ ? Prioritas sistem kesehatan pada negara berkembang Dukungan organisasi internasional atau organisasi philanthropic pada penyakit tersebut Visibilitasnya rendah

Neglected Diseases (WHO) Buruli Ulcer ( Mycobacterium ulcerans infection) Onchocerciasis (River blindness) Foodborne trematodiases Rabies Human African trypanosomiasis (Sleeping sickness) Schistosomiasis Soil transmitted helminthiases Chagas disease Dengue/Severe dengue Taeniasis/Cystice rcosis Leishmaniasis Dracunculiasis (guinea-worm disease) Leprosy Trachoma Lymphatic filariasis Yaws (Endemic treponematoses) Echinococcosis

With What Diseases Should be Compared With? Neglected Diseases Other Diseases 1.1% dari 1.393 drugs approvals Little or no Funds Less Researched 12.8% for Cardiovascular Disease Most of Budget for Malaria and Tuberculosis More Researched: HIV/AIDS, CHD, TB, Malaria, Cancer.

WHY ?? Complex pathogen life cycles that are laborious and often expensive to maintain in the laboratory Limited molecular tools for genetic manipulation and analysis on a genome-wide scale Limitead animal models of infection that mimic the human disease

What implications that some disease have been neglected in medical research? Menyengsarakan kehidupan serta mengancam kesehatan banyak manusia Memperlemah populasi ekonomi rendah Mempersulit pencapaian target MDG mengganggu global public health outcomes

QUESTIONS? Thank You

References http://www.niaid.nih.gov/topics/tropicalDiseases/documen ts/ntd.pdf http://www.medicusmundi.ch/mms/services/bulletin/bulleti n200401/kap01/08burri.html http://blog.wellcome.ac.uk/2012/01/10/neglected-tropical- diseases-the-campaign-trail/ http://www.who.int/neglected_diseases/diseases/en/ http://www.who.int/neglected_diseases/2010report/en/